Global Dynamics and Implications of an HBV Model with Proliferating Infected Hepatocytes
نویسندگان
چکیده
Chronic hepatitis B (HBV) infection is a major cause of human suffering, and number mathematical models have examined the within-host dynamics disease. Most previous assumed that infected hepatocytes do not proliferate; however, effect HBV on hepatocyte proliferation controversial, with conflicting data showing both induction inhibition proliferation. With family ordinary differential equation (ODE) models, we explored dynamical impact among HBV-infected hepatocytes. Here, show in this class generates threshold divides into two categories. Sufficiently compromised cells produces complex characterized by oscillating viral loads, whereas higher straightforward always results chronic infection, sometimes liver failure. A global stability result failure state was included as it unique to models. Finally, model analysis motivated testable biological hypothesis: Healthy are present if only severely impaired.
منابع مشابه
The Role of Proliferating Infected Hepatocytes on the Dynamics of an HBV-infected Liver
Chronic hepatitis B (HBV) infection is a major cause of human suffering, and a number of mathematical models have examined within-host dynamics of the disease. Previous models assume that infected hepatocytes do not proliferate; however, the effect of HBV infection on hepatocyte proliferation is controversial, with conflicting data showing both induction and inhibition of proliferation. With a ...
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2021
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app11178176